There are a few things to take into account.
Bank Angle: Degrees between cylinders on the same crank journal
Manifold Configuration: Equal Length, Un-Equal length, Tuned
Lets start with Bank Angle, this effects the time between BANG on cylinders on a common journal. The wider the angle, the more spaced out the bang will be. Keep in mind you can have cylinders on a common journal fire on the same stroke, or opposing strokes with the bank angle further effecting how far out the cylinders are from one another.
I will be using two cylinder engines to example what is happening.
Inline Twin: With a Common crank angle you will have two modes of firing: 360° or 0° (pop-360-pop-360-pop-360-pop, or POWx2-360-missx2-360-POWx2-360-missx2)
V-Twin 90°: With a Common crank angle you can have a firing 360°(270) or 0°(90) (pop-270-pop-90-miss-270-miss-90-pop, or pop-90-pop-270-miss-90-miss-270-pop
That effects sound substantially.
Next is Manifold construction.
Un-Equal: Lets pretend we have an Inline-2 firing at 0° with a common crank angle. If you make one cylinders manifold twice the length of the other, it would sound like an engine firing at 360° at the tailpipe.
With Equal length you will always hear the exhaust pulses matching with the degree of difference to the cylinders.
Tuned: This is where un-equal length meets science. Cylinders which are 180° from one other are mated, so the exhaust pulse from one cylinder will pass the union right as the exhaust valve from another cylinder is opening. Promoting the scavenging effect to help make a more efficient fresh air charge.
A Tuned manifold can make a Subie sound like a Honda, or make a X-plane V8 sound like a FPV8 it is entirely up to the man man who makes the manifolds. A 4 could sound like a twin, or a 8 could sound like a 4.
Last is Crank angle, this makes things even more confusing, but to keep it short, if you made a cross plane i4, you could make it sound similar to a V8, or with a tuned header, make it sound like a normal i4.
Hope this was helpful.