You could probably still make most post-war stuff, since even things like 30s fords should be doable if you do some minor adjustements as needed.
As long as it's not an open wheeler, you could probably make something decent.
Pickup trucks also present similar issues with the back suspension (and with fixtures clipping through the inner walls of the box), but you can work around that by making the box less deep than it should be and the walls thicker. Won't be 100% like in real life but it will still look fairly good.
The main issue is dealing with UVW mapping on older cars with external fenders like the 30s fords and very old pickups. I am actually surprised I got it to work acceptably on the 50s truck.